Oral Solid Dosage Form

Prescriptions for successful solutions

北京快三开奖结果彩票控 www.8hib.cn While an apple a day keeps the doctor away (and the teacher happy) there comes a time, in almost everyone's life, when medication - in tablet form - is needed.  Our knowledge of the structure function of polymers, combined with our extensive product line can help you bind, coat, dissolve, and effectively deliver complex drug molecules where and when they're needed - making medication easier to swallow.  And, easy to swallow medication often yields better patient compliance,  which, in turn, yields better outcomes for everyone - a winning scenario. From concept to commericialization, working with Ashland makes medicine easy to swallow.

Ashland is unsurpassed in its ability to develop solutions for effective and efficient solutions to deliver today's complex drug molecules where and when they are needed.  Our centers of excellence and manufacturing sites operate in accordance with cGMP standards. Our various chemistries and technologies are supported by a global team of research and development scientists. Ashland stands ready collaborate with you on new solutions to help take you from concept to commercialization.  Our solutions include:

  • Increasing the solubility of active pharmaceutical ingredients with low or no solubility
  • Designing modified-release products to meet targeted release profiles
  • Reducing tablet size while maintaining active pharmaceutical ingredient load
  • Improving disintegration time of orally disintegrating tablets
  • Understanding implications of continuous manufacturing technology for oral dosage production

Ongoing research provides a foundation for advanced technical solutions to address these and future formulation and manufacturing challenges. Ashland provides formulators with industry-changing technologies and unique opportunities for research and development collaboration.

 

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Aqualon™ ethylcellulose (EC) is a cellulose ether distinguished by its versatility. As a unique product with wide-ranging solubility and flexibility at low temperatures, ethylcellulose is frequently used in electronics in addition to a variety of other applications. It provides high solution clarity, good thermal stability, even burnout and has very low decomposition temperatures. Aqualon EC is a key binder for gravure printing inks as well...

Aqualon? ethylcellulose

Our line of fully formulated, easily dispersed and ready-to-use Aquarius™ film coating systems have a range of functions to suit almost any core. With our wide selection of film coating choices, we can provide an optimal coating for your unique formulation. The regulatory compliance information for all Ashland products varies by product family and grade. For specific data about the grade you are interested in please refer to our Excipient I...

Aquarius? film coating systems

AquaSolve™ HPMCAS for pharmaceutical applications is a cellulosic polymer with four substituents randomly substituted on the available hydroxyl groups with the following mass content: methoxyl, 12–18 wt%; hydroxypropoxy, 4–23 wt%; acetyl, 2–16 wt% and succinoyl, 4–28 wt%. It is white to off-white in color and has a faint acetic acid-like odor and a barely detectable taste.  AquaSolve HPMCAS is available in sever...

AquaSolve? hypromellose acetate succinate

Benecel™ methylcellulose and hypromellose (hydroxypropyl-methylcellulose or HPMC) are versatile excipients with a variety of applications. High-viscosity grades are widely used in hydrophilic matrix controlled-release systems. Low-viscosity grades are used as the primary film former in tablet coatings and vegetarian capsule formulations, and are a common wet-granulation tablet binder. Hypromellose is used as a solid dispersions solubilizer ...

Benecel? methylcellulose and hypromellose

Blanose™ sodium carboxymethylcellulose (CMC) is made by reacting sodium monochloroacetate with alkalicellulose under rigidly controlled conditions. The resultant anionic polymer is purified and dried.  Purified CMC for personal care and cosmetic applications is typically sold at 99.5 percent minimum purity. In addition to thickening aqueous systems, CMC is used in personal care products for water binding, syneresis control and its abil...

Blanose? sodium carboxymethylcellulose

The molecular structure of cyclodextrins creates a bucket-like cavity that can complex with molecules or functional groups on molecules to improve solubility of poorly soluble compounds. The same mechanism makes these excipients capable of masking unpleasant taste/odor and stabilizing drugs that are prone to degradation. The number of glucose units in the ring determines the internal diameter of the cavity and its volume, as the height of the cyc...

CAVAMAX? native cyclodextrins

Klucel? hydroxypropylcellulose (HPC) is a nonionic water-soluble cellulose ether with a remarkable combination of properties. It combines organic solvent solubility, thermoplasticity and surface activity with the aqueous thickening and stabilizing properties characteristic of other water-soluble cellulose polymers available from Ashland. Klucel HPC films are flexible without plasticizers and non-tacky at high humidity.

Klucel? hydroxypropylcellulose

Natrosol™ hydroxyethylcellulose (HEC), a nonionic, water-soluble polymer, is a white, free-flowing granular powder. It is made by reacting ethylene oxide with alkali-cellulose under rigidly controlled conditions. Purified HEC for personal care and cosmetic applications is typically sold at 95.0 percent minimum purity (dry basis).  Solutions of Natrosol HEC are pseudoplastic or shear-thinning. As a result, personal care products formula...

Natrosol? hydroxyethylcellulose

Aqualon™ sodium carboxymethylcellulose (CMC) is made by reacting sodium monochloroacetate with alkalicellulose under rigidly controlled conditions. The resultant anionic polymer is purified and dried. Purified CMC for personal care and cosmetic applications is typically sold at 99.5 percent minimum purity. In addition to thickening aqueous systems, CMC is used in personal care products for water binding, syneresis control and its ability to...

Aqualon? sodium carboxymethylcellulose

Ashland offers a comprehensive range of Plasdone povidones (PVP). Plasdone povidones are a family of water-soluble polymers based on N-vinylpyrrolidone that combine a unique set of properties for application in a wide variety of dosage forms. Plasdone povidones are commonly used as binders for the development of tablet formulations, whether manufactured by wet granulation, dry granulation or direct compression. Plasdone K polymers are used in sol...

Plasdone? povidone

Plasdone™ S-630 copovidone is a tablet binder, matrix polymer for solid-dispersion formulations and film former for topical applications. It is commonly used to enhance the solubility of active pharmaceutical ingredients and increase bioavailability of poorly soluble drugs through the formation of melt-extruded or spray-dried solid dispersions. The regulatory compliance information for all Ashland products varies by product family and grade...

Plasdone? S-630 copovidone

Polyplasdone™ crospovidone superdisintegrants are synthetic, insoluble, but rapidly swellable, crosslinked homopolymers of N-vinyl-2-pyrrolidone. Crospovidone provides rapid disintegration and dissolution to oral solid dosage forms. Polyplasdone crospovidone particles are granular and porous compared with other superdisintegrants. The high surface area combined with unique chemistry results in high interfacial activity that enhances the dis...

Polyplasdone? crospovidone

Pharmasolve™ N-methyl-2-pyrrolidone (NMP) is a water-miscible polar aprotic solvent with high interfacial activity. It is used as a drug solubilizer and penetration enhancer in human topical dosage forms, and for the same purposes in parenteral and topical veterinary products. The regulatory compliance information for all Ashland products varies by product family and grade. For specific data about the grade you are interested in please refe...

Pharmasolve? N-methyl-2-pyrrolidone

The molecular structure of cyclodextrins creates a bucket-like cavity that can function to complex with molecules or functional groups on molecules. The substitution of hydroxyl groups on native cyclodextrins to make hydroxypropyl-ß- or hydroxypropyl-γ-cyclodextrins (HPBCD or HBGCD) significantly enhances their solubility and makes them more suitable for drug solubilization. This mechanism makes the CAVASOL HPBCDs and HPGCDs capable o...

Cavitron* cyclodextrin and CAVASOL* cyclodextrin

Aquarius Preferred film coating systems disperse easily in water. These film coatings are applicable to both pharmaceutical and nutraceutical solid dosage forms. Ashland formulators have access to an unrivaled range of cellulosic and other polymeric excipients, enabling Aquarius film coating systems to be tailored to meet exacting requirements. To maximize the efficiency of the coating application process, high-solids loadings are desirable. By r...

Aquarius? preferred film coating systems

The Aquarius Control film coating systems consist of two types of coatings. Aquarius Control ENA film coating systems are delayed-release (enteric) coatings that are designed to protect active pharmaceutical ingredients (APIs) that degrade in gastric fluid, or to prevent the release of APIs that may irritate the gastric mucosa. Aquarius Control SRX film coating systems are sustained-release coatings for APIs that are most effective when released ...

Aquarius? Control film coating systems

Aquarius Prime film coating systems disperse easily in water and are applied to immediate-release dosage forms. Film coatings for immediate-release tablet-coating applications are typically comprised of a polymer, a plasticizer and optional pigment/opacifier. Aquarius Prime film coating systems are available in clear and white formulations off the shelf. Aquarius Prime film coating systems can be matched to customers’ existing HPMC fil...

Aquarius? Prime film coating systems

Aquarius™ Protect is a premium multi-functional barrier coating system to effectively reduce moisture uptake and mask against offensive taste and odor. For easier usability, Aquarius™ Protect is a fully formulated, ready-mixed coating that disperses quickly in water or solvent and is available in clear, white and color matched versions. Aquarius™ Protect delivers superior barrier properties and efficient flexible processing, wit...

Aquarius? Protect film coating systems

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